Presurgical evaluation in children with drug-resistant epilepsy. Results of the CIREN

Abstract

OBJECTIVE: To present the results obtained in presurgical evaluation of patients in pediatric age with farmacoresistant epilepsy.

METHODS: We evaluated 50 children between 2-18 years, with an average duration of epilepsy 5.68 ± 4.65. Records of Video-EEG (V-EEG) behavioral and electrographic variables were analyzed, and the results were compared with those obtained in adult patients.

RESULTS: The efficiency of the monitoring V-EEG was 0. 83± 0.16 crisis/day, with statistically significant difference with adults, p = 0.02. The crisis/day, both waking and dream number was higher in children than in adults, p = 0.01, p = 0.04 respectively. The analysis of electroclinical patterns allowed to define in 54 % of patients the diagnosis of extratemporal epilepsy, 45 % temporal, and 10 % generalized. These results were statistically significant to compare them with adults. It shows the relationship of the ictal onset zone with epileptogenic lesion demonstrated by images of magnetic resonance imaging (MRI), as well as the use of multimodal images when the MRI negative turned out with special emphasis on the EEG and SPECT co-registry interictal and ictal and methods of sources solution generated by EEG ictal.

CONCLUSIONS: The results obtained support the feasibility of evaluating presurgical patients with drug-resistant epilepsy for the development of epilepsy surgery as a therapeutic alternative in the pediatric age.