El filtraje sensorial como una función adaptativa esencial para el humano
Texto completo:
PDFResumen
Objetivo: Describir los mecanismos implicados en el filtraje sensorial y su evaluación mediante las técnicas de Neurofisiología Clínica.
Adquisición de la evidencia: Se realizó una búsqueda de los últimos veinte años en la base de datos PubMed con las palabras clave: sensory gating; sensory gating AND event-related potentials, epilepsy y schizophrenia. Se revisaron un total de 97 artículos en idiomas inglés y español.
Resultados: El fallo en el filtraje sensorial podría ocasionar una capacidad cerebral deteriorada para seleccionar, procesar y almacenar información, lo que puede contribuir de manera significativa a una disfunción cognitiva o psicosis. Se basa en índices tales como la supresión de P50, N100 y P200, y la inhibición por prepulso de la respuesta de sobresalto. Su evaluación se realiza básicamente mediante el cálculo del cociente de amplitud de los componentes ante el primer y segundo estímulo (S2/S1) y su diferencia de amplitud (S1-S2). Los generadores de sus componentes varían en dependencia de la modalidad sensorial de que se trate. Para la exploración auditiva se propone que los generadores del componente P50 se ubiquen a nivel de lóbulo temporal, en tanto el proceso de filtraje propiamente tiene lugar en áreas del lóbulo frontal.
Conclusiones: Los reportes en la literatura apoyan el uso de las técnicas de Neurofisiología Clínica para el estudio de los mecanismos implicados en el filtraje sensorial y sus alteraciones en diversas enfermedades del sistema nervioso central.
Palabras clave
Referencias
Srna S, Schrift RY, Zauberman G. The illusion of multitasking and its positive effect on performance. Psychol Sci. 2018; 29 (12). Doi: 10.1177/0956797618801013
Boutros NN, Campbell D, Torello M. Correlations between four components of sensory gating. Biol Psychiatry. 2000;47:1S-173S.
Heckman PRA, Van Duinen MA, Blokland A, Uz T, Prickaerts J, Sambeth A. Acute administration of roflumilast enhances sensory gating in healthy young humans in a randomized trial. Psychopharmacology (Berl). 2018;235:301-8.
Hubka P, Kral A. Lateral inhibition and its role in the physiology of sensory organs. Bratisl Lek Listy. 1999;100(10):572-5.
Boutros NN, Trautner P, Korzyukov O, Grunwald T, Burroughs S, Elger CE, et al. Mid-latency auditory-evoked responses and sensory gating in focal epilepsy: a preliminary exploration. J Neuropsychiatry Clin Neurosci. 2006;18:409-16.
Boutros NN, Gjini K, Eickhoff SB, Urbach H, Pflieger ME. Mapping repetition suppression of the P50 evoked response to the human cerebral cortex. Clin Neurophysiol. 2013;124:675-85.
Takeuchi N, Sugiyama S, Inui K, Kanemoto K, Nishihara M. New paradigm for auditory paired pulse suppression. PLoS One. 2017;12:e0177747.
Arenas MC, Caballero-Reinaldo C, Navarro-Frances CI, Manzanedo C. Effects of cocaine on prepulse inhibition of the startle response. Rev Neurol. 2017;65:507-19.
Jones LA, Hills PJ, Dick KM, Jones SP, Bright P. Cognitive mechanisms associated with auditory sensory gating. Brain Cogn. 2016;102:33-45.
Rentzsch J, Kronenberg G, Stadtmann A, Neuhaus A, Montag C, Hellweg R, Jockers-Scherübl MC. Opposing effects of cannabis use on late auditory repetition suppression in schizophrenia patients and healthy control subjects. Biol Psychiatry Cogn Neurosci Neuroimaging. 2017;2(3):263-71.
Almaguer-Melian W, Bergado JA, Lopez-Rojas J, Frey S, Frey JU. Differential effects of electrical stimulation patterns, motivational-behavioral stimuli and their order of application on functional plasticity processes within one input in the dentate gyrus of freely moving rats in vivo. Neuroscience. 2010;165:1556-8.
Ethridge LE, White SP, Mosconi MW, Wang J, Byerly MJ, Sweeney JA. Reduced habituation of auditory evoked potentials indicate cortical hyper-excitability in Fragile X syndrome. Transl. Psychiatry. 2016;6:e787.
Gonzalez-Heydrich J, Bosquet Enlow M, D'Angelo D, Seidman LJ, Gumlak S, Kim A, et al. N100 repetition suppression indexes neuroplastic defects in clinical high risk and psychotic youth. Neural Plasticity. 2016 (1): 4209831 Doi: 10.1155/2016/4209831.
Boland KM, Stichter JP, Beversdorf DQ, Christ SE. Brief report: Flanker visual filtering ability in older adolescents with autism spectrum disorder. J Autism Dev Disord. 2019 Jan;49(1):422-8.
Bak N, Glenthoj BY, Rostrup E, Larsson HB, Oranje B. Source localization of sensory gating: a combined EEG and fMRI study in healthy volunteers. Neuroimage. 2011;54:2711-8.
Arpin DJ, Gehringer JE, Wilson TW, Kurz MJA. Reduced somatosensory gating response in individuals with multiple sclerosis is related to walking impairment. J Neurophysiol. 2017;118:2052-8.
Thoma RJ, Meier A, Houck J, Clark VP, Lewine JD, Turner J, Calhoun V, Stephen J. Diminished auditory sensory gating during active auditory verbal hallucinations. Schizophr Res. 2017;188:125-31.
Huang WL, Liu CY, Liu HM, Liu CM, Hsieh MH. Sex as a moderating factor in the relationship between hippocampal volume and sensory gating in patients with schizophrenia. Clin EEG Neurosci. 2019;50:227-30.
Lauer AM. Acoustic startle modification as a tool for evaluating auditory function of the mouse: progress, pitfalls, and potential. Neurosci Biobehav Rev. 2017;77:194-208.
Swerdlow NR, Braff DL, Geyer MA. Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next. J Psychopharmacol. 2016;30:1072-81.
Schwabe K, Krauss JK. What rodent models of deep brain stimulation can teach us about the neural circuit regulation of prepulse inhibition in neuropsychiatric disorders. Schizophr Res. 2018;198:45-51.
Li XB, Bo QJ, Tian Q, Yang NB, Mao Z, Zheng W, et al. Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia. BMC Psychiatry. 2018 Aug 16;18(1):258. Doi: 10.1186/s12888-018-1807-7.
García-Sánchez F, Martínez-Gras I, Rodríguez-Jiménez R, Rubio G. Prepulse inhibition of the startle response/reflex in neuropsychiatric disorders. Rev Neurol. 2011;53:422-32.
Chang WP, Arfken CL, Sangal MP, Boutros NN. Probing the relative contribution of the first and second responses to sensory gating indices: a meta-analysis. Psychophysiology. 2011;48:980-92.
Korzyukov O, Pflieger ME, Wagner M, Bowyer SM, Rosburg T, Sundaresan K, et al. Generators of the intracranial P50 response in auditory sensory gating. Neuroimage. 2007;35:814-26.
Cheng CH, Baillet S, Lin YY. Region-specific reduction of auditory sensory gating in older adults. Brain Cogn. 2015;101:64-72.
Spooner RK, Wiesman AI, Proskovec AL, Heinrichs-Graham E, Wilson TW. Rhythmic spontaneous activity mediates the age-related decline in somatosensory function. Cereb Cortex. 2019;29:680-8.
Grunwald T, Boutros NN, Pezer N, von Oertzen J, Fernandez G, Schaller C, et al. Neuronal substrates of sensory gating within the human brain. Biol Psychiatry. 2003;53:511-9.
Golubic SJ, Jurasic MJ, Susac A, Huonker R, Gotz T, Haueisen J. Attention modulates topology and dynamics of auditory sensory gating. Hum. Brain Mapp. 2019;40:2981-94.
Hsiao FJ, Wang SJ, Lin YY, Fuh JL, Ko YC, Wang PN, et al. Somatosensory gating is altered and associated with migraine chronification: a magnetoencephalographic study. Cephalalgia. 2018;38:744-53.
Uygunoglu U, Gunduz A, Ertem HD, Uluduz D, Saip S, Goksan B, et al. Deficient prepulse inhibition of blink reflex in migraine and its relation to allodynia. Neurophysiol Clin. 2017;47(1):63-8.
Millian-Morell L, Lopez-Alburquerque T, Rodriguez-Rodriguez A, Gomez-Nieto R, Carro J, Meilan JJG, et al. Relations between sensorimotor integration and speech disorders in Parkinson's disease. Curr Alzheimer Res. 2018;15:149-56.
Cheng CH, Chan PS, Hsu SC, Liu CY. Abnormal frontal generator during auditory sensory gating in panic disorder: an MEG study. Psychiatry Res Neuroimaging. 2019;288:60-6.
Atagun MI, Drukker M, Hall MH, Altun IK, Tatli SZ, Guloksuz S, et al. Meta-analysis of auditory P50 sensory gating in schizophrenia and bipolar disorder. Psychiatry Res Neuroimaging. 2020 Jun 30;300:111078. Doi: 10.1016/j.pscychresns.2020.111078.
LaGasse AB, Manning RCB, Crasta JE, Gavin WJ, Davies PL. Assessing the impact of music therapy on sensory gating and attention in children with autism: a pilot and feasibility study. J Music Ther. 2019;56:287-314.
Cheng CH, Chan PS, Hsu SC, Liu CY. Meta-analysis of sensorimotor gating in patients with autism spectrum disorders. Psychiatry Res. 2018;262:413-9.
Sinclair D, Oranje B, Razak KA, Siegel SJ, Schmid S. Sensory processing in autism spectrum disorders and Fragile X syndrome-from the clinic to animal models. Neurosci Biobehav Rev. 2017;76:235-53.
Storozheva ZI, Akhapkin RV, Bolotina OV, Korendrukhina A, Novototsky-Vlasov VY, Shcherbakova IV, et al. Sensorimotor and sensory gating in depression, anxiety, and their comorbidity. World J Biol Psychiatry. 2020;5:1-11.
Conte A, Belvisi D, De Bartolo MI, Manzo N, Cortese FN, Tartaglia M, et al. Abnormal sensory gating in patients with different types of focal dystonias. Mov Disord. 2018;33:1910-7.
Sedley W. Tinnitus: does gain explain? Neuroscience. 2019;407:213-28.
Ku Y, Ahn JW, Kwon C, Kim DY, Suh MW, Park MK, et al. The gap-prepulse inhibition deficit of the cortical N1-P2 complex in patients with tinnitus: the effect of gap duration. Hear Res. 2017;348:120-8.
Peter B, McCollum H, Daliri A, Panagiotides H. Auditory gating in adults with dyslexia: an ERP account of diminished rapid neural adaptation. Clin Neurophysiol. 2019;130:2182-92.
Rosburg T, Trautner P, Fell J, Moxon KA, Elger CE, Boutros NN. Sensory gating in intracranial recordings-the role of phase locking. Neuroimage. 2009;44:1041-9.
Kiziltan ME, Alpaslan BG, Ozkara C, Uzan M, Gunduz A. Role of mesial temporal lobe structures in sensory processing in humans: a prepulse modulation study in temporal lobe epilepsy. Exp. Brain Res. 2018;236:3297-305.
Hornix BE, Havekes R, Kas MJH. Multisensory cortical processing and dysfunction across the neuropsychiatric spectrum. Neurosci Biobehav Rev. 2019;97:138-51.
Swerdlow NR, Light GA. Animal models of deficient sensorimotor gating in schizophrenia: are they still relevant? Curr Top. Behav. Neurosci. 2016;28:305-25.
Luck SJ, Leonard CJ, Hahn B, Gold JM. Is attentional filtering impaired in schizophrenia? Schizophr Bull. 2019;45:1001-11.
Schubring D, Popov T, Miller GA, Rockstroh B. Consistency of abnormal sensory gating in first-admission and chronic schizophrenia across quantification methods. Psychophysiology. 2018;55(4). Doi: 10.1111/psyp.13006.
Mendoza Quiñones R, Martín Reyes M, Díaz de Villalvila Ramón T. Evaluación de las anomalías perceptuales en pacientes esquizofrénicos y sus familiares de primer grado. Rev. CENIC (Ciencias Biológicas). 2002;33:106-10.
Earls HA, Curran T, Mittal V. A meta-analytic review of auditory event-related potential components as endophenotypes for schizophrenia: perspectives from first-degree relatives. Schizophr. Bull. 2016;42:1504-16.
Hashimoto K. Targeting of á7 nicotinic acetylcholine receptors in the treatment of schizophrenia and the use of auditory sensory gating as a translational biomarker. Curr Pharm Des. 2015;21:3797-806.
Hamilton HK, Williams TJ, Ventura J, Jasperse LJ, Owens EM, Miller GA, et al. Clinical and cognitive significance of auditory sensory processing deficits in schizophrenia. Am J Psychiatry. 2018;175:275-83.
Rosburg T. Auditory N100 gating in patients with schizophrenia: a systematic meta-analysis. Clin Neurophysiol. 2018;129:2099-111.
Bak N, Mann J, Fagerlund B, Glenthoj BY, Jepsen JRM, Oranje B. Testing a decades' old assumption: are individuals with lower sensory gating indeed more easily distracted? Psychiatry Res. 2017;255:387-93.
Vlcek P, Bob P, Raboch J. Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia. Neuropsychiatr Dis Treat. 2014;10:1309-15.
Wan L, Thomas Z, Pisipati S, Jarvis SP, Boutros NN. Inhibitory deficits in prepulse inhibition, sensory gating, and antisaccade eye movement in schizotypy. Int J Psychophysiol. 2017;114:47-54.
Morales-Muñoz I, Jurado-Barba R, Fernández-Guinea S, Rodríguez-Jiménez R, Jiménez-Arriero MÁ, Criado JR, et al. Sensory gating deficits in first-episode psychosis: evidence from neurophysiology, psychophysiology, and neuropsychology. J Nerv Ment Dis. 2016;204(12):877-84.
Swerdlow NR, Bhakta SG, Talledo JA, Franz DM, Hughes EL, Rana BK, et al. Effects of amphetamine on sensorimotor gating and neurocognition in antipsychotic-medicated schizophrenia patients. Neuropsychopharmacology. 2018;43(4):708-17.
Micoulaud-Franchi JA, Faugere M, Boyer L, Cermolacce M, Fond G, Richieri R, et al. Sensory gating deficits and impaired quality of life in patients with schizophrenia: A preliminary study. Psychiatr Danub. 2016;28(3):225-33.
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.
La revista está: Certificada por el CITMA
La revista es de acceso abierto y gratuito.