El CIREN y la nueva neurología

Jorge Alberto Bergado Rosado, María Luisa Rodríguez Cordero

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Resumen

INTRODUCCIÓN: Con la creación en 1989 del CIREN, Cuba entró en la nueva era de la neurología. Durante la segunda mitad del siglo XX los conceptos de la neurociencia evolucionaron del estatismo a un sistema adaptable y cambiante, moldeado por la experiencia, a través de la propiedad de plasticidad neuronal. El objetivo del trabajo es presentar los logros más relevantes de este esfuerzo de investigación en esta institución.

DESARROLLO: Además de la atención de pacientes cubanos y extranjeros, se ha desarrollado una intensa investigación sobre todas las herramientas potenciales que podrían servir para recuperar o restaurar la función nerviosa afectada por traumatismos o enfermedad. El paso inicial fue el trasplante neural de células dopaminérgicas a pacientes parkinsonianos. Otras intervenciones de la neurocirugía funcional o resectiva también se intentaron para trastornos del movimiento o epilepsia. La investigación básica ha contribuido a confirmar los beneficios esperados para tratar con éxito los trastornos degenerativos, y los programas de neurorrehabilitación diseñados tratan de inducir un entorno promotor de la plasticidad para maximizar la recuperación.

CONCLUSIONES: La investigación en el CIREN ocupa un lugar privilegiado. Algunos resultados han traído nuevos tratamientos clínicos y quirúrgicos. Otros, principalmente los de investigación básica, aún no han encontrado una traducción terapéutica. Pero todos han contribuido en gran medida a dar forma al perfil único de esta institución cubana. La manera de avanzar en los pasos firmes hacia ese objetivo, es el camino de una ciencia sólida y de alto nivel.

Palabras clave

Cuba; Historia; Neurocirugía Funcional; Neurología Restaurativa; Neurorrehabilitación; Plasticidad Neural

Referencias

Molina H, Quinones-Molina R, Munoz J, Alvarez L, Alaminos A, Ortega I, et al. Neurotransplantation in Parkinson's disease: from open microsurgery to bilateral stereotactic approach: first clinical trial using microelectrode recording technique. Stereotact Funct Neurosurg. 1994;62(1-4):204-8.

Morales-Chacon LM, Macias-Gonzalez R, Torres A, Alvarez L, Munoz J. Contribution of thalamic somatosensory evoked potentials to stereotaxic thalamometry. Rev Neurol. 1997 Jul;25(143):1025-30.

Quinones-Molina R, Molina H, Ohye C, Macias R, Alaminos A, Alvarez L, et al. CT-oriented microrecording guided selective thalamotomy. Stereotact Funct Neurosurg. 1994;62(1-4):200-3.

Alvarez Gonzalez LM, Macías Gonzalez RJ, López Flores G, Alvarez Gonzalez E, Maragoro Rizo C, García Maeso I, et al. Selective posteroventral pallidotomy guided by semimicroregister in the treatment of advanced stages of idiopathic Parkinson´s disease. Rev Mex Neurosci. 2001;2(2):87-96.

Baez-Martin M, Morales-Chacon L, Gomez-Fernandez L, Macias Gonzalez RJ. Potenciales corticales relacionados a movimientos en pacientes parkinsonianos sometidos a tratamiento quirúrgico neurorrestaurativo. Rev Neurol Arg. 1996;21:73-8.

Alvarez L, Macias R, Guridi J, Lopez G, Alvarez E, Maragoto C, et al. Dorsal subthalamotomy for Parkinson's disease. Mov Disord. 2001 Jan;16(1):72-8.

Lopez-Flores G, Miguel-Morales J, Teijeiro-Amador J, Vitek J, Perez-Parra S, Fernandez-Melo R, et al. Anatomic and neurophysiological methods for the targeting and lesioning of the subthalamic nucleus: Cuban experience and review. Neurosurgery. 2003 Apr;52(4):817-30.

Lopez FG, Morales JM, Tejeiro-Amador J, Fernandez-Melo R, Alvarez-Gonzalez L, Macias-Gonzalez R, et al. Subthalamic nucleus targeting and spatial variability. Rev Neurol. 2003 Sep 1;37(5):404-12.

Alvarez L, Macias R, Pavon N, Lopez G, Rodriguez-Oroz MC, Rodriguez R, et al. Therapeutic efficacy of unilateral subthalamotomy in Parkinson's disease: results in 89 patients followed for up to 36 months. J Neurol Neurosurg Psychiatry. 2009 Sep;80(9):979-85.

Alvarez L, Macias R, Lopez G, Alvarez E, Pavon N, Rodriguez-Oroz MC, et al. Bilateral subthalamotomy in Parkinson's disease: initial and long-term response. Brain. 2005 Mar;128(Pt 3):570-83.

Obeso JA, Rodriguez-Oroz MC, Rodriguez M, Macias R, Alvarez L, Guridi J, et al. Pathophysiologic basis of surgery for Parkinson's disease. Neurology. 2000;55(12 Suppl 6):S7-12.

Obeso JA, Rodriguez MC, Gorospe A, Guridi J, Alvarez L, Macias R. Surgical treatment of Parkinson's disease. Baillieres Clin Neurol. 1997 Apr;6(1):125-45.

Obeso JA, Rodriguez MC, Guridi J, Alvarez L, Alvarez E, Macias R, et al. Lesion of the basal ganglia and surgery for Parkinson disease. Arch Neurol. 2001 Jul;58(7):1165-6.

Obeso JA, Jahanshahi M, Alvarez L, Macias R, Pedroso I, Wilkinson L, et al. What can man do without basal ganglia motor output? The effect of combined unilateral subthalamotomy and pallidotomy in a patient with Parkinson's disease. Exp Neurol. 2009 Dec;220(2):283-92.

Obeso I, Wilkinson L, Casabona E, Bringas ML, Alvarez M, Alvarez L, et al. Deficits in inhibitory control and conflict resolution on cognitive and motor tasks in Parkinson's disease. Exp Brain Res. 2011 Jul;212(3):371-84.

Obeso I, Casabona E, Bringas ML, Alvarez L, Jahanshahi M. Semantic and phonemic verbal fluency in Parkinson's disease: Influence of clinical and demographic variables. Behav Neurol. 2012;25(2):111-8.

Vera-Cuesta H, Vera-Acosta H, Alvarez-Gonzalez L, Fernandez-Maderos I, Casabona-Fernandez E. Frontal dysfunction in idiopathic Parkinson's disease. Rev Neurol. 2006 Jan 16;42(2):76-84.

Obeso I, Wilkinson L, Casabona E, Speekenbrink M, Luisa BM, Alvarez M, et al. The subthalamic nucleus and inhibitory control: impact of subthalamotomy in Parkinson's disease. Brain 2014 May;137(Pt 5):1470-80.

Bickel S, Alvarez L, Macias R, Pavon N, Leon M, Fernandez C, et al. Cognitive and neuropsychiatric effects of subthalamotomy for Parkinson's disease. Parkinsonism Relat Disord. 2010 Sep;16(8):535-9.

Rodriguez-Oroz MC, Jahanshahi M, Krack P, Litvan I, Macias R, Bezard E, et al. Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms. Lancet Neurol. 2009 Dec;8(12):1128-39.

Voon V, Fernagut PO, Wickens J, Baunez C, Rodriguez M, Pavon N, et al. Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders. Lancet Neurol. 2009 Dec;8(12):1140-9.

Martinez-Martin P, Rodriguez-Blazquez C, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, Chade A, et al. Expanded and independent validation of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS). J Neurol. 2013 Jan;260(1):228-36.

Martinez-Martin P, Chaudhuri KR, Rojo-Abuin JM, Rodriguez-Blazquez C, Alvarez-Sanchez M, Arakaki T, et al. Assessing the non-motor symptoms of Parkinson's disease: MDS-UPDRS and NMS Scale. Eur J Neurol. 2013 Apr 22.

Martinez-Martin P, Rodriguez-Blazquez C, Forjaz MJ, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, et al. Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients. Eur J Neurol. 2014 Mar;21(3):519-24.

Martinez-Martin P, Rodriguez-Blazquez C, Alvarez M, Arakaki T, Arillo VC, Chana P, et al. Parkinson's disease severity levels and MDS-Unified Parkinson's Disease Rating Scale. Parkinsonism Relat Disord. 2015 Jan;21(1):50-4.

Alvarez SM, Padron-Sanchez A, Alvarez Gonzalez LM, Pedroso-Ibanez I, Díaz de la Fe A. Guías de práctica clínicas basadas en la evidencia: enfermedad de Parkinson. La Habana: Ciencias Médicas; 2011.

Torres MA, Pereira J. Testing the precision of stereotactic planning systems. Comput Med Imaging Graph. 1998 Jul;22(4):317-21.

Carballo-Barreda M, Rodriguez-Rojas R, Torres-Montoya A, Lopez-Flores G. Computerized atlas for image-guided stereotactic functional neurosurgery. Neurocirugia (Astur). 2007 Dec;18(6):478-84.

López Flores G, Guerra Figueredo E, Ochoa Zaldívar L, Padrón A, Torres A, Morales JM, et al. Stereotaxic microsurgical resection of intracranial tumors guided by imaging and assisted by computer. Rev Neurol. 2001 Mar 1;32(5):417-22.

Macias R, Teijeiro J, Torres A, Alvarez L. Electrophysiological targeting in stereotaxic surgery for Parkinson's disease. Adv Neurol. 1997;74:175-82.

Teijeiro AJ, Macias Gonzalez RJ, Ohye C, Munoz Aguilar JL, Alvarez Gonzalez LM, Ochoa ZL, et al. Automatic anatomic-physiologic correspondence of deep structures of the central nervous system in stereotaxic functional neurosurgery. Neurologia. 1996 Nov;11(9):320-31.

Teijeiro EJ, Macias RJ, Morales JM, Guerra E, Lopez G, Alvarez LM, et al. An automatic system for anatomophysiological correlation in three planes simultaneously during functional neurosurgery. Rev Neurol. 2001 Jun 1;32(11):1005-12.

Teijeiro J, Macias RJ, Morales JM, Guerra E, Lopez G, Alvarez LM, et al. Personal-computer-based system for three-dimensional anatomic-physiological correlations during stereotactic and functional neurosurgery. Stereotact Funct Neurosurg. 2000;75(4):176-87.

Teijeiro J, Macias RJ, Maragoto C, Garcia I, Alvarez M, Quintanal NE. Deep brain recording and length of surgery in stereotactic and functional neurosurgery for movement disorders. Neurocirugia (Astur). 2014 May;25(3):116-27.

Pavon N, Vidal L, Alvarez P, Blanco L, Torres A, Rodriguez A, et al. Behavioral evaluation of the unilateral lesion model in rats using 6-hydroxydopamine. Correlation between the rotations induced by D-amphetamine, apomorphine and the manual dexterity test. Rev Neurol. 1998 Jun;26(154):915-8.

Alvarez P, de la Cuetera K, Garcia JC, Castellanos O, Francis L, Macias R, et al. Embryonic Cell Suspension Grafts in a Rat Model of Parkinson's Disease. J Neural Transplant Plast. 1992;3(4):222.

Fernandez C, de la Cuetara K, Castellanos O, Gonzalez O, Nunez N, Alvarez L, et al. Brain aging and neurotransplantation. I. Nigral cell suspension graft to aged rodent striatum and motor disabilities. Arch Gerontol Geriatr. 1994;19 Suppl 1:51-8.

Fernandez CI, Bergado J, de la Cuetara K, Nunez N, Castellanos O, Gonzalez O, et al. Brain aging and neurotransplantation. II. Effects of septal cell suspension grafts to hippocampus of aged rodents on learning and memory impairments. Arch Gerontol Geriatr. 1994;19 Suppl 1:59-65.

Alvarez-Fonseca P, Blanco L, Pavon N, Vidal L, Castellano O, Castillo L, et al. Simultaneous transplantation of fetal mesencephalic cells to the striatum and globus pallidus of rats with lesions induced by 6-hydroxydopamine. Rev Neurol. 1998 Apr;26(152):537-40.

Blanco L, Pavon N, Alvarez P, Diaz C, Castellano O, Castillo L, et al. Transplantation of fetal dopaminergic cells simultaneously to the corpus striatum and pars reticularis of the substantia nigra in hemi-parkinsonian rats. Rev Neurol. 1998 Mar;26(151):361-5.

Blanco L, Pavon N, Macias R, Castillo L, Diaz C, Garcia A, et al. Simultaneous micro-transplantation of fetal mesencephalic cells to the striate and substantia nigra pars reticulata in hemi-parkinsonian rats. A study of behavior. Rev Neurol. 2000 Jun 16;30(12):1122-7.

Pavon-Fuentes N, Macias-Gonzalez R, Blanco-Lezcano L, Alvarez-Gonzalez L, Martinez-Marti L, Castillo-Diaz L, et al. Effects of simultaneous transplant of foetal mesencephalic cells in the striatum and the subthalamic nucleus of hemiparkinsonian rats. Rev Neurol. 2002 May 16;34(10):917-23.

Pavon-Fuentes N, Blanco-Lezcano L, Martinez-Martin L, Castillo-Diaz L, Cuetara-Bernal K, Garcia-Miniet R, et al. Stromal cell transplant in the 6-OHDA lesion model. Rev Neurol. 2004 Aug 16;39(4):326-34.

Garcia JC, Cruz R, Leiva A, Alvarez P, Soto Y, McPherson M. Lesion of nigrostriatal neurons by 6-hydroxydopamine induces changes in rat brain glutathione-S-transferase. Mol Chem Neuropathol. 1997 Jun;31(2):149-59.

Cruz-Aguado R, Francis-Turner L, Diaz CM, Antunez I. Quinolinic acid lesion induces changes in rat striatal glutathione metabolism. Neurochem Int. 2000 Jul;37(1):53-60.

Diaz-Hung ML, Gonzalez Fraguela ME. Oxidative stress in neurological diseases: Cause or effect? Neurologia. 2013; 29(8):451-2.

Gonzalez-Fraguela ME, Castellano-Benitez O, Gonzalez-Hoyuela M. Oxidative stress in neurodegeneration. Rev Neurol. 1999 Mar 1;28(5):504-11.

Gonzalez-Fraguela ME, Robinson MA, Delgado R. A study of the oxidative stress indicators in elderly monkeys. Rev Neurol 2000 Dec 1;31(11):1012-5.

Diaz-Hung ML, Blanco L, Pavon N, Leon R, Estupinan B, Orta E, et al. Sensory-motor performance after acute glutathione depletion by L-buthionine sulfoximine injection into substantia nigra pars compacta. Behav Brain Res. 2014 Sep 1;271:286-93.

Fernandez CI, Collazo J, Bauza Y, Castellanos MR, Lopez O. Environmental enrichment-behavior-oxidative stress interactions in the aged rat: issues for a therapeutic approach in human aging. Ann N Y Acad Sci. 2004 Jun;1019:53-7.

Cruz-Aguado R, Almaguer-Melian W, Diaz CM, Lorigados L, Bergado J. Behavioral and biochemical effects of glutathione depletion in the rat brain. Brain Res Bull. 2001 Jun;55(3):327-33.

Almaguer-Melian W, Cruz-Aguado R, Bergado JA. Synaptic plasticity is impaired in rats with a low glutathione content. Synapse. 2000 Dec 15;38(4):369-74.

Cruz-Aguado R, Fernandez-Verdecia CI, Diaz-Suarez CM, Gonzalez-Monzon O, Antunez-Potashkina I, Bergado-Rosado J. Effects of nerve growth factor on brain glutathione-related enzymes from aged rats. Fundam Clin Pharmacol. 1998;12(5):538-45.

Pavon N, Martin AB, Mendialdua A, Moratalla R. ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice. Biol Psychiatry 2006 Jan 1;59(1):64-74.

Blanco-Lezcano L, Rocha-Arrieta LL, Martinez-Marti L, Alvarez-Gonzalez L, Pavon-Fuentes N, Macias-Gonzalez R, et al. Lesions in the pars compacta substantiae nigra and the subthalamic nucleus modify the density of muscarinic receptors in different nuclei of the basal ganglia. Rev Neurol. 2004 Jan 16;38(2):128-32.

Blanco-Lezcano L, Rocha-Arrieta LL, Alvarez-Gonzalez L, Martinez-Marti L, Pavon-Fuentes N, Gonzalez-Fraguela ME, et al. The effects of lesions in the compact part of the substantia nigra on glutamate and GABA release in the pedunculopontine nucleus. Rev Neurol. 2005 Jan 1;40(1):23-9.

Blanco-Lezcano L, Pavon-Fuentes N, Serrano-Sanchez T, Blanco-Lezcano V, Coro-Grave de PY, Joseph-Bouza Y. The pedunculopontine nucleus. A structure involved in motor and emotional processing. Rev Neurol. 2003 Jun 16;36(12):1181-5.

Blanco Lezcano L, Lorigados Pedre LC, Orozco Suárez S, Rocha Arrieta L, Pavón Fuentes N, González Fraguela ME, et al. Changes in Glu and GABA extracellular concentrations and cell death process in the pedunculopontine nucleus of hemiparkinsonian rats. J Biol Res –Thessalon. 2009 Jan 1;11:3-11.

Blanco L, Yuste JE, Carrillo-de Sauvage MA, Gomez A, Fernandez-Villalba E, Aviles-Olmos I, et al. Critical evaluation of the anatomical location of the Barrington nucleus: relevance for deep brain stimulation surgery of pedunculopontine tegmental nucleus. Neuroscience. 2013 Sep 5;247:351-63.

Blanco L, Ros CM, Tarragon E, Fernandez-Villalba E, Herrero MT. Functional role of Barrington's nucleus in the micturition reflex: relevance in the surgical treatment of Parkinson's disease. Neuroscience. 2014 Apr 25;266:150-61.

Jimenez-Martin J, Blanco-Lezcano L, Gonzalez-Fraguela ME, Diaz-Hung ML, Serrano-Sanchez T, Almenares JL, et al. Effect of neurotoxic lesion of pedunculopontine nucleus in nigral and striatal redox balance and motor performance in rats. Neuroscience. 2015 Mar 19; 289:300-14.

Francis L, Cruz R, Antunez I, Rosillo JC. Behavior characterization of a model of Huntington's disease in rats, induced by quinolinic acid. Rev Neurol. 2000 Jun 1;30(11):1016-21.

Cuetara-Bernal K, Castillo-Diaz L, Cruz-Aguado R, Gonzalez-Mena Y, Garcia-Varona AY. In vitro viability and glutathione levels in mesencephalic neurons after seven days hibernation. Rev Neurol. 2002 Jun 1;34(11):1030-4.

Cuetara-Bernal K, Castillo-Diaz L, Martinez-Marti L, Garcia-Varona AY. Survival of dopaminergic neurons that were hibernated in vitro for seven days. Rev Neurol. 2005 Feb 1;40(3):145-9.

Chacón Morales LM, Sanchez CC, Quincoses Trápaga O, Lorigados Pedre L, Rudy, Die Dierckx RA. Nuclear Medicine Neuroimaging and Electromagnetic Source Localization in Nonlesional Drug-Resistant Focal Epilepsy. PET and SPECT in Neurology. Springer; 2014. p. 843-60.

Morales-Chacon L. Magnetic resonance spectroscopy and functional magnetic resonance images: non-invasive alternatives for identifying epileptogenic foci. Rev Neurol. 2001 Feb 1;32(3):234-6.

Morales-Chacon L, Bosch-Bayard J, Valdes P, Zaldivar M. Cerebral electrical tomography in congenital bilateral perisylvian syndrome. Rev Neurol. 2001 Feb 16;32(4):397-9.

Morales-Chacon LM, Bosch-Bayard J, Bender-del Busto JE, Garcia-Maeso I, Galan-Garcia L. Video-EEG evaluation complemented by spectral and EEG source analysis in patients with medication-resistant medial temporal lobe epilepsy. Rev Neurol. 2007 Feb 1;44(3):139-45.

Morales-Chacon LM, Alfredo Sanchez CC, Minou Baez MM, Rodriguez RR, Lorigados PL, Estupinan DB. Multimodal imaging in nonlesional medically intractable focal epilepsy. Front Biosci (Elite Ed). 2015 Jan 1;7:42-57.

Morales-Chacon L, Bosch-Bayard J, Valdes-Sosa P, Ortega-Perez MA, Zaldivar M, Sanchez A. Brain electromagnetic tomography distinguishes primary generalised discharges from secondary bilateral synchrony. Rev Neurol. 2003 Mar 1;36(5):498-9.

Morales Chacon LM, Sanchez CC, Bender JE, Bosch-Bayard J, García ME, García Maeso I, et al. A Neurofunctional Evaluation Strategy for Presurgical Selection of Temporal Lobe Epilepsy Patients. MEDICC Review. 2009;11(1):29-35.

Morales-Chacon LM. Electrocorticografía intraoperatoria en la epilepsia del lóbulo temporal con patología dual. In: Cornejo Ochoa W, Toro Pérez M, editors. Epilepsias del lóbulo temporal. Medellín: Universidad de Antioquia; 2011. p. 153-61.

Bender del Busto JE, González González J. Evaluación clínica pre y postquirúgica de pacientes con epilepsia refractaria. Lineamientos para el tratamiento de las epilepsias farmacorresistentes en Cuba. La Habana: OPS; 2014. p. 18-31.

Baez-Martin MM, Cabrera-Abreu I. Effects of lobectomy on the auditory mid-latency response in temporal lobe epileptic patients. Rev Neurol. 2005 Jul 16;41(2):81-5.

Baez-Martin MM, Morales-Chacon LM, Garcia-Maeso I, Estupinan-Diaz B, Lorigados-Pedre L, Garcia ME, et al. Temporal lobe epilepsy surgery modulates the activity of auditory pathway. Epilepsy Res. 2014 May;108(4):748-54.

Baez Martin MM, del Carmen Perez TY, Chacon LM, Diaz BE, Trapaga-Quincoses O, Maeso IG, et al. Innovative evaluation of visual field defects in epileptic patients after standard anterior temporal lobectomy, using partial field visual evoked potentials. Epilepsy Res. 2010 Jun;90(1-2):68-74.

Estupinan-Diaz B, Morales-Chacon LM, Lorigados-Pedre L, Garcia-Maeso I, Bender-del Busto JE, Trapaga-Quincoses O, et al. Pathological neocortical findings in patients with medication-resistant medial temporal lobe epilepsy submitted to surgery. Rev Neurol. 2008 Feb 16;46(4):203-9.

Estupinan-Diaz B, Morales-Chacon L, Garcia-Maeso I, Lorigados-Pedre L, Salazar Rodriguez C, Gomez H, et al. Asociación de tumores neuroepiteliales y displasia cortical focal microscópica en pacientes con epilepsia del lobulo temporal fármaco resistente. Rev Ecuat Neurol. 2009;18(3):43-50.

Estupinan-Diaz BO, Morales-Chacon LM, Garcia-Maeso I, Lorigados-Pedre L, Baez-Martin M, Garcia-Navarro ME, et al. Corpora amylacea in the neocortex in patients with temporal lobe epilepsy and focal cortical dysplasia. Neurologia. 2015 Mar;30(2):90-6.

Lopez J, Gonzalez ME, Lorigados L, Morales L, Riveron G, Bauza JY. Oxidative stress markers in surgically treated patients with refractory epilepsy. Clin Biochem. 2007 Mar;40(5-6):292-8.

Lorigados-Pedre L, Morales-Chacon L, Pavon-Fuentes N, Serrano-Sanchez T, Robinson-Agramonte MA, Garcia-Navarro ME, et al. Immunological disorders in epileptic patients are associated to the epileptogenic focus localization. Rev Neurol. 2004 Jul 16;39(2):101-4.

Lorigados PL, Morales Chacon LM, Orozco SS, Pavon FN, Estupinan DB, Serrano ST, et al. Inflammatory mediators in epilepsy. Curr Pharm Des. 2013;19(38):6766-72.

Morales CL, Estupinan B, Lorigados PL, Trapaga QO, Garcia M, I, Sanchez A, et al. Microscopic mild focal cortical dysplasia in temporal lobe dual pathology: an electrocorticography study. Seizure. 2009 Oct;18(8):593-600.

Rocha L, Lorigados-Pedre L, Orozco-Suarez S, Morales-Chacon L, Alonso-Vanegas M, Garcia-Maeso I, et al. Autoradiography reveals selective changes in serotonin binding in neocortex of patients with temporal lobe epilepsy. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Aug 15;31(6):1208-18.

Morales-Chacon LM. Lineamientos del Capítulo Cubano de la ILAE para la evaluación y tratamiento quirúrgico de las epilepsias intratables con medicamentos. Lineamientos para el tratamiento de las epilepsias farmacorresistentes en Cuba. La Habana: OPS; 2014. p. 9-17.

Bergado-Rosado JA, Almaguer-Melian W. Cellular mechanisms of neuroplasticity. Rev Neurol. 2000 Dec 1;31(11):1074-95.

Senmanat Belisón A. Neurorrehabilitación multifactorial intensiva. La Habana: Ciencias Médicas; 1998.

Sentmanat Belisón A. Sistema de neurorehabilitación multifactorial intensiva. En: ISCF Manuel Fajardo, editor. Ejercicios Físicos y Rehabilitación. La Habana: Deportes; 2006. p. 232-87.

Crespo Moinelo M, Gomez Perez R, Ortiz Anton G, Francia Gonzalez T, Bringas Vega ML, Boys Lam O, et al. Propuesta pedagogica para la compensacion de la memoria visoespacial en pacientes con secuelas neurologicas. Rev Ecuat Neurol. 2011;20(1-3):34-42.

Crespo Moinelo M, Gomez Perez R, Ortiz Anton G, Bringas Vega ML. Sistema de actividades para la compensación de la memoria de trabajo en adultos con ataxia por trauma craneoencefálico. Rev Ecuat Neurol. 2011;20(1-3):55-9.

Gutierrez de los Santos R, Aguero Pacheco E, Carballo Perez e, Martinez Aching G. Combinación de un programa de rehabilitación y estimulo eléctrico en pie equino para las alteraciones de la marcha en niños con parálisis cerebral. Rev Ecuat Neurol. 2010;18(3):31-4.

Torres Carro OO. Parkinson: manual de entrenamiento motor. México: Lindero; 2001.

Torres Carro OO. Parkinson: qué debe usted conocer. México: Lindero; 2002.

Torres Carro OO. Cómo mantener la independencia: para pacientes con limitaciones motoras. San Pedro Sula (Honduras): Propasa; 2002.

Torres Carro OO. Parkinson: cómo mejorar la destreza manual y la escritura: Sistema Oligraf. México: Lindero; 2002.

Torres Carro OO, Arocha S. Estrategia pedagógica para los parkinsonianos: un reto pedagógico. Caracas: Liceo Bolivariano “Gustavo H. Machado”; 2006.

Torres Carro OO. Afasia: qué debe usted saber. Santiago: Universidad Chilena de Salud Mental; 2015.

Rodriguez-Mutuberria L, Alvarez-Gonzalez L, Lopez M, Bender-del Busto JE, Fernandez-Martinez E, Martinez-Segon S, et al. Efficacy and tolerance of a neurological restoration program in stroke patients. NeuroRehabilitation. 2011;29(4):381-91.

Fernández Gómez L, Alvarez-Gonzalez E, Macías Betancourt R, Galvizu Sánchez R, Palmero R, Padilla Puentes E, et al. Modificaciones en las proyecciones córtico-motoneuronales que van a la mano en pacientes que reciben rehabilitación intensiva. Rehabilitación. (Madrid) 2006;40(2):79-86.

Abreu de la Torre C, Suarez-Monteagudo C, Araujo-Suarez F. Depression in patient with neurological diseases. Proposed therapeutic strategies. Rev Neurol. 2001 Feb 16;32(4):393-5.

Frey S, Bergado-Rosado J, Seidenbecher T, Pape HC, Frey JU. Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala: heterosynaptic induction mechanisms of late-LTP. J Neurosci. 2001 May 15;21(10):3697-703.

Almaguer-Melian W, Martinez-Marti L, Frey JU, Bergado JA. The amygdala is part of the behavioural reinforcement system modulating long-term potentiation in rat hippocampus. Neuroscience. 2003;119(2):319-22.

Bergado JA, Almaguer-Melian W, Kostenko S, Frey S, Frey JU. Behavioral reinforcement of long-term potentiation in rat dentate gyrus in vivo is protein synthesis-dependent. Neurosci Lett. 2003 Nov 6;351(1):56-8.

Almaguer-Melian W, Rojas-Reyes Y, Alvare A, Rosillo JC, Frey JU, Bergado JA. Long-term potentiation in the dentate gyrus in freely moving rats is reinforced by intraventricular application of norepinephrine, but not oxotremorine. Neurobiol Learn Mem. 2005 Jan;83(1):72-8.

Bergado JA, Frey S, Lopez J, Almaguer-Melian W, Frey JU. Cholinergic afferents to the locus coeruleus and noradrenergic afferents to the medial septum mediate LTP-reinforcement in the dentate gyrus by stimulation of the amygdala. Neurobiol Learn Mem. 2007 Oct;88(3):331-41.

Frey S, Bergado JA, Frey JU. Modulation of late phases of long-term potentiation in rat dentate gyrus by stimulation of the medial septum. Neuroscience. 2003;118(4):1055-62.

Almaguer-Melian W, Rosillo JC, Frey JU, Bergado JA. Subcortical deafferentation impairs behavioral reinforcement of long-term potentiation in the dentate gyrus of freely moving rats. Neuroscience. 2006;138(4):1083-8.

Jas J, Almaguer W, Frey JU, Bergado J. Lesioning the fimbria-fornix impairs basolateral amygdala induced reinforcement of LTP in the dentate gyrus. Brain Res. 2000 Apr 7;861(1):186-9.

Kudolo J, Tabassum H, Frey S, Lopez J, Hassan H, Frey JU, et al. Electrical and pharmacological manipulations of the nucleus accumbens core impair synaptic plasticity in the dentate gyrus of the rat. Neuroscience. 2010 Jul 14;168(3):723-31.

Lopez-Rojas J, Almaguer-Melian W, Bergado-Rosado JA. Synaptic tagging and memory trace. Rev Neurol. 2007 Nov 16;45(10):607-14.

Bergado JA, Scherf T, Almaguer-Melian W, Frey S, Lopez J, Frey JU. Stimulation of the nucleus raphe medialis modifies basal synaptic transmission at the dentate gyrus, but not long-term potentiation or its reinforcement by stimulation of the basolateral amygdala. Neurosci Lett. 2009 Oct 30;464(3):179-83.

Almaguer-Melian W, Cruz-Aguado R, Riva CL, Kendrick KM, Frey JU, Bergado J. Effect of LTP-reinforcing paradigms on neurotransmitter release in the dentate gyrus of young and aged rats. Biochem Biophys Res Commun. 2005 Feb 18;327(3):877-83.

Almaguer W, Estupinan B, Uwe FJ, Bergado JA. Aging impairs amygdala-hippocampus interactions involved in hippocampal LTP. Neurobiol Aging. 2002 Mar;23(2):319-24.

Bergado JA, Almaguer W, Ravelo J, Rosillo JC, Frey JU. Behavioral reinforcement of long-term potentiation is impaired in aged rats with cognitive deficiencies. Neuroscience. 2001;108(1):1-5.

Bergado JA, Almaguer W, Rojas Y, Capdevila V, Frey JU. Spatial and emotional memory in aged rats: a behavioral-statistical analysis. Neuroscience. 2011 Jan 13;172:256-69.

Bergado JA, Rojas Y, Capdevila V, Gonzalez O, Almaguer-Melian W. Stimulation of the basolateral amygdala improves the acquisition of a motor skill. Restor Neurol Neurosci. 2006;24(2):115-21.

Almaguer W, Capdevila V, Ramirez M, Vallejo A, Rosillo JC, Bergado JA. Post-training stimulation of the basolateral amygdala improves spatial learning in rats with lesion of the fimbria-fornix. Restor Neurol Neurosci. 2005;23(1):43-50.

Merceron-Martinez D, Almaguer-Melian W, Serrano T, Lorigados L, Pavon N, Bergado JA. Hippocampal neurotrophins after stimulation of the basolateral amygdala, and memory improvement in lesioned rats. Restor Neurol Neurosci. 2013;31(2):189-97.

Almaguer-Melian W, Bergado-Rosado J, Pavon-Fuentes N, Alberti-Amador E, Merceron-Martinez D, Frey JU. Novelty exposure overcomes foot shock-induced spatial-memory impairment by processes of synaptic-tagging in rats. Proc Natl Acad Sci USA. 2012 Jan 17;109(3):953-8.

Almaguer-Melian W, Bergado JA, Lopez-Rojas J, Frey S, Frey JU. Differential effects of electrical stimulation patterns, motivational-behavioral stimuli and their order of application on functional plasticity processes within one input in the dentate gyrus of freely moving rats in vivo. Neuroscience. 2010 Feb 17;165(4):1546-58.

Almaguer-Melian W, Bergado JA, Martinez-Marti L, Duany-Machado C, Frey JU. Basolateral amygdala stimulation does not recruit LTP at depotentiated synapses. Physiol Behav. 2010 Nov 2;101(4):549-53.

Bergado JA, Lucas M, Richter-Levin G. Emotional tagging--a simple hypothesis in a complex reality. Prog Neurobiol. 2011 Jun;94(1):64-76.

Gomez L, Vidal B, Morales L, Baez M, Maragoto C, Galvizu R, et al. Low frequency repetitive transcranial magnetic stimulation in children with attention deficit/hyperactivity disorder. Preliminary results. Brain Stimul. 2014 Sep;7(5):760-2.

Gomez FL, Padilla Puentes E, Cabrera-Abreu I, Zaldívar Bermúdez M, Morales-Chacon L, Sanchez-Coroneaux A, et al. Estimulación magnética transcraneal repetitiva y rehabilitación intensiva en pacientes con infarto cerebral. Rev Mex Neuroci. 2016;17(5):15-25.

Castellanos-Ortega MR, Cruz-Aguado R, Martinez-Marti L. Nerve growth factor: possibilities and limitations of its clinical application. Rev Neurol. 1999 Sep 1;29(5):439-47.

Lorigados-Pedre L, Bergado-Rosado J. Nerve growth factor in neurodegeneration and neurorestorative therapy. Rev Neurol. 2004 May 16;38(10):957-71.

Lorigados L, Soderstrom S, Ebendal T. Two-site enzyme immunoassay for beta NGF applied to human patient sera. J Neurosci Res. 1992 Jul;32(3):329-39.

Lorigados L, Molina H, Serrano T, Pavon N, Robinson MA, Alvarez L, et al. Evolutive levels of NGF in neurodegenerative disorders. Mol Chem Neuropathol. 1995 Feb;24(2-3):231-4.

Lorigados L, Alvarez P, Pavon N, Serrano T, Blanco L, Macias R. NGF in experimental models of Parkinson disease. Mol Chem Neuropathol. 1996 May;28(1-3):225-8.

Lorigados PL, Pavon FN, Alvarez GL, McRae A, Serrano ST, Blanco LL, et al. Nerve growth factor levels in Parkinson disease and experimental parkinsonian rats. Brain Res. 2002 Oct 11;952(1):122-7.

Serrano T, Lorigados LC, Armenteros S. Nerve growth factor levels in normal human sera. Neuroreport 1996 Dec 20;8(1):179-81.

Lorigados L, Pavon N, Serrano T, Robinson MA. Nerve growth factor and neurological diseases. Rev Neurol. 1998 May;26(153):744-8.

Lorigados L, Pavon N, Serrano T, Robinson MA, Fernandez CI, Alvarez P. Changes in nerve growth factor levels related to age and neurotrophic treatment in non-human primate. Rev Neurol. 2001 Sep 1;33(5):417-21.

Serrano-Sanchez T, Robinson-Agramonte MA, Lorigados-Pedre L, Diaz-Armesto I, Gonzalez-Fraguela ME, Dorta-Contreras AJ. Endogenous nerve growth factor in patients with Alzheimer s disease. Rev Neurol. 2001 May 1;32(9):825-8.

Castellanos Ortega MR, Cruz AR, Lorigados PL, de la Cuetara BK. Purification and characterization of murine beta-nerve growth factor. J Chromatogr B Biomed Sci Appl. 2001 Apr 5;753(2):245-52.

Castellanos MR, Moya G, Cruz R, Lorigados L, Fernandez CI, Diaz C, et al. Obtention and characterization of murine beta-NGF. Application in a model of cerebral aging. Rev Neurol. 1998 May;26(153):717-22.

Francis-Turner L, Valouskova V, Mokry J. The long-term effect of NGF, b-FGF and Cerebrolysin on the spatial memory after fimbria-fornix lesion in rats. J Neural Transm Suppl 1996;47:277.

Castellanos MR, Aguiar J, Fernandez CI, Almaguer W, Mejias C, Varela A. Evaluation of the neurorestorative effects of the murine beta-nerve growth factor infusions in old rat with cognitive deficit. Biochem Biophys Res Commun. 2003 Dec 26;312(4):867-72.

Fernandez CI, Gonzalez O, Soto J, Alvarez L, Quijano Z. Effects of chronic infusion of nerve growth factor (NGF) in AF64A-lesioned rats. Mol Chem Neuropathol. 1996 May;28(1-3):175-9.

Fernandez CI, Gonzalez O, Soto J, Alvarez L, Lores T. Effects of chronic infusion of nerve growth factor (NGF) in rats with nucleus basalis magnocellularis lesion. Mol Chem Neuropathol. 1996 May;28(1-3):181-4.

Francis-Turner L, Valouskova V. Nerve growth factor and nootropic drug Cerebrolysin but not fibroblast growth factor can reduce spatial memory impairment elicited by fimbria-fornix transection: short-term study. Neurosci Lett. 1996 Jan 5;202(3):193-6.

Bergado JA, Fernandez CI, Gomez-Soria A, Gonzalez O. Chronic intraventricular infusion with NGF improves LTP in old cognitively-impaired rats. Brain Res. 1997 Oct 3;770(1-2):1-9.

Bergado JA, Gomez-Soria AA, Cruz R, Fernandez CI. Nerve growth factor improves evoked potentials and long-term potentiation in the dentate gyrus of presenile rats. Eur J Pharmacol. 1998 Mar 19;345(2):181-4.

Cruz-Aguado R, Turner LF, Diaz CM, Pinero J. Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease. Restor Neurol Neurosci. 2000;17(4):217-21.

Cruz-Aguado R, Francis-Turner L, Diaz-Suarez CM, Bergado J. NGF prevents changes in rat brain glutathione-related enzymes following transection of the septohippocampal pathway. Neurochem Int. 1999 Feb;34(2):125-30.

Morales-Chacon L, Baez-Martin M, Fernandez-Verdecia I, Lopez V, Diaz L. Follow-up study of the evolution of the quantitative EEG in intraventricular infusion of nerve growth factor in an aged baboon. Rev Neurol. 1997 Jun;25(142):850-5.

Castillo L, Martinez L, Grygar E, Hutter-Paier B. Characterization of proliferation and differentiation of EGF-responsive striatal and septal precursor cells. Int J Dev Neurosci. 2003 Feb;21(1):41-7.

Castillo-Diaz L, Castellano-Benitez O, Soto-Alonso J, Rosillo-Marti JC, Cuetara-Bernal K. The action of epidermal growth factor on the development of cultured striatum cells. Rev Neurol. 1997 Oct;25(146):1511-7.

Castillo-Diaz L, Cuetara-Bernal K, Garcia-Varona AY. Marrow stromal cells cultured in N2-supplemented medium: implications on the generation of neural cells. Rev Neurol. 2005 Jan 16;40(2):69-73.

Castillo L, Grygar E, Hutter-Paier B. Epidermal growth factor-responsive precursors with similar properties isolated from embryonic rat septum and striatum. Rev Neurol. 2000 Jul 1;31(1):26-31.

Garcia R, Aguiar J, Alberti E, de la Cuetara K, Pavon N. Bone marrow stromal cells produce nerve growth factor and glial cell line-derived neurotrophic factors. Biochem Biophys Res Commun. 2004 Apr 9;316(3):753-4.

Almaguer-Melian W, Merceron-Martinez D, Delgado-Ocana S, Pavon-Fuentes N, Ledon N, Bergado JA. EPO induces changes in synaptic transmission and plasticity in the dentate gyrus of rats. Synapse. 2016;70(6):240-52.

Almaguer-Melian W, Merceron-Martinez D, Pavon-Fuentes N, Alberti-Amador E, Leon-Martinez R, Ledon N, et al. Erythropoietin Promotes Neural Plasticity and Spatial Memory Recovery in Fimbria-Fornix-Lesioned Rats. Neurorehabil Neural Repair. 2015 Nov;29(10):979-88.

Pedroso I, Bringas ML FAU - Aguiar A, Aguiar AF, Morales LF, Alvarez MF, Valdes PA FAU - Alvarez L, et al. Use of Cuban recombinant human erythropoietin in Parkinson's disease treatment. MEDICC Rev. 2012;14(1):11-7.

Alberti-Amador E, Garcia-Miniet R. Bone marrow stromal cells. An alternative source of restorative therapy in degenerative diseases of the central nervous system. Rev Neurol. 2003 Oct 16;37(8):752-8.

Hombach-Klonisch S, Panigrahi S, Rashedi I, Seifert A, Alberti E, Pocar P, et al. Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med (Berl). 2008 Dec;86(12):1301-14.

Alberti E, Los M, Garcia R, Fraga JL, Serrano T, Hernandez E, et al. Prolonged survival and expression of neural markers by bone marrow-derived stem cells transplanted into brain lesions. Med Sci Monit. 2009 Feb;15(2):BR47-BR54.

Alberti-Amador E, Garcia-Miniet R, Serrano-Sanchez T, Blanco-Lezcano L, Martinez-Marti L, Mendoza-Mari Y, et al. Evaluation of the survival of bone marrow mononucleate cells transplanted in a rat model of striatal lesion with quinolinic acid. Rev Neurol. 2005 May 1;40(9):518-22.

Fernandez CI, Alberti E, Mendoza Y, Martinez L, Collazo J, Rosillo JC, et al. Motor and cognitive recovery induced by bone marrow stem cells grafted to striatum and hippocampus of impaired aged rats: functional and therapeutic considerations. Ann N Y Acad Sci. 2004 Jun;1019:48-52.

Suarez-Monteagudo C, Hernandez-Ramirez P, Alvarez-Gonzalez L, Garcia-Maeso I, Cuetara-Bernal K, Castillo-Diaz L, et al. Autologous bone marrow stem cell neurotransplantation in stroke patients. An open study. Restor Neurol Neurosci. 2009;27(3):151-61.

Serrano T, Pierozan P, Alberti A, Blanco L, de la Cuétara Bernal K, González ME, et al. Transplantation of mononuclear cells from bone marrow in a rat model of Huntington's disease. J Neurorestoratology. 2016;4:1-11.

Cabrera-Gomez JA, Kurtzke JF, Gonzalez-Quevedo A, Lara-Rodriguez R. An epidemiological study of neuromyelitis optica in Cuba. J Neurol. 2009 Jan;256(1):35-44.

Robinson-Agramonte M, Reiber H, Cabrera-Gomez JA, Galvizu R. Intrathecal polyspecific immune response to neurotropic viruses in multiple sclerosis: a comparative report from Cuban patients. Acta Neurol Scand. 2007 May;115(5):312-8.

Cabrera-Gomez JA, Echazabal-Santana N, Real-Gonzalez Y, Romero GK, Junior SM, Gil Ocana MA, et al. Hereditary Melkersson-Rosenthal syndrome and multiple sclerosis. Mult Scler. 2005 Jun;11(3):364-6.

Penton-Rol G, Cervantes-Llanos M, Cabrera-Gomez JA, Alonso-Ramirez R, Valenzuela-Silva C, Rodriguez-Lara R, et al. Treatment with type I interferons induces a regulatory T cell subset in peripheral blood mononuclear cells from multiple sclerosis patients. Int Immunopharmacol. 2008 Jun;8(6):881-6.

Baez-Martin M, Cruz Menor M, Cabrera-Abreu I, Cabrera-Gomez JA, Galvizu-Sanchez R. Valor potencial evocado auditivo de latencia media en el estudio de personas con esclerosis multiple forma-brote-remision. Rev Ecuat Neurol. 2007;16(2):69-76.

Cabrera-Gomez JA, Santana E, Vals O, Casanova M, Alfaro I, Gonzalez-Quevedo A, et al. Clinical characterization of patients with multiple sclerosis defined in Cuba. Rev Neurol 1998 May;26(153):723-8.

Cabrera-Gomez JA, Lopez-Saura P. Recent advances in the treatment the nervous system disorders with interferon-alpha. Rev Neurol. 1999 Dec 16;29(12):1225-35.

Cabrera-Gomez JA, Santana-Capote E, Echazabal-Santana N, Diaz dlF, Casanova M, Gomez L, et al. Actual status of multiple sclerosis in Cuba. National cooperative group for the clinical trial “Recombinant interferon alpha-2b in multiple sclerosis”. Rev Neurol. 2000 Sep 1;31(5):482-93.

Gomez-Fernandez L, Macias-Gonzalez RJ, Mustelier R, Estrada R, Gamez-Morales L, Paz-Sendin L. Investigation of corticospinal dysfunction in multiple sclerosis and motoneuron diseases using motor evoked potentials. Rev Neurol. 1996 Dec;24(136):1507-12.

Gomez-Fernandez L, Salas R, Calzada D, Maragoto C, Perez-Lache N, Sanchez-Catasus C, et al. Association of parkinsonism, dementia and amyotrophic lateral sclerosis as infrequent finding. Rev Neurol. 1999 Apr 1;28(7):738.

Hernandez-Valero E, Cabrera-Gomez JA, Valenzuela C. Clinical features of multiple sclerosis in Western Cuba. A comparison with two other regions in the country. Rev Neurol. 2004 May 1;38(9):818-23.

Hernandez-Valero E, Cabrera-Gomez JA. The influence of geographical background on the clinical and neurophysiological characteristics of patients with multiple sclerosis in Cuba. Rev Neurol. 2004 Feb 16;38(4):311-5.

Robinson Agramonte MA, Reiber H, Dorta Contreras AJ, Hernandez DE. Intrathecal oligoclonal and polyspecific immune response in multiple sclerosis. Rev Neurol. 2001 Nov 1;33(9):809-11.

Robinson-Agramonte MA, Goncalves CA, Portela LV, Saiz-Hinarejos A, Oses JP, Motta LS, et al. Differential regulation of IgG-NMO autoantibodies on S100Beta protein and disability in relapsing neuromyelitis optica. Neuroimmunomodulation. 2010;17(3):177-9.

Cabrera-Gomez JA, Kister I. Conventional brain MRI in neuromyelitis optica. Eur J Neurol. 2012 Jun;19(6):812-9.

Cabrera-Gomez JA, Quevedo-Sotolongo L, Gonzalez-Quevedo A, Lima S, Real-Gonzalez Y, Cristofol-Corominas M, et al. Brain magnetic resonance imaging findings in relapsing neuromyelitis optica. Mult Scler. 2007 Mar;13(2):186-92.

Cabrera-Gomez J, Saiz-Hinarejos A, Graus F, Gonzalez-Quevedo A, Rodriguez-Rojas R, Quevedo-Sotolongo L, et al. Brain magnetic resonance imaging findings in acute relapses of neuromyelitis optica spectrum disorders. Mult Scler. 2008 Mar;14(2):248-51.

Cabrera-Gomez JA, Ramon-Perez L, Saiz A, Llerena-Fernandez P, Fernandez-Fernandez L, Ercilla G, et al. Neuromyelitis optica and multiple sclerosis in sisters. Mult Scler. 2009 Feb;15(2):269-71.

Cabrera-Gomez JA, Bonnan M, Gonzalez-Quevedo A, Saiz-Hinarejos A, Marignier R, Olindo S, et al. Neuromyelitis optica positive antibodies confer a worse course in relapsing-neuromyelitis optica in Cuba and French West Indies. Mult Scler. 2009 Jul;15(7):828-33.

Penton-Rol G, Cervantes-Llanos M, Martinez-Sanchez G, Cabrera-Gomez JA, Valenzuela-Silva CM, Ramirez-Nunez O, et al. TNF-alpha and IL-10 downregulation and marked oxidative stress in Neuromyelitis Optica. J Inflamm (Lond). 2009;6:18.

Sanchez-Catasus CA, Cabrera-Gomez J, Almaguer MW, Giroud Benitez JL, Rodriguez RR, Bayard JB, et al. Brain Tissue Volumes and Perfusion Change with the Number of Optic Neuritis Attacks in Relapsing Neuromyelitis Optica: A Voxel-Based Correlation Study. PLoS One. 2013;8(6):e66271.

Obeso JA, Rodriguez-Oroz MC, Guridi M, Macias R, Ramos E, Linazasoro G, et al. Cirugía de los trastornos del movimiento y función de los ganglios basales. Neurologia. 2014;15(Supl 5):37-49.

Sanchez-Catasus CA, Cabrera-Gomez J, Almaguer MW, Bosch BJ, Rodriguez RR, Valdes-Sosa P. The number of optic neuritis attacks is a potential confounder when comparing patients with NMO vs. controls by voxel-based neuroimaging analysis. Acta Radiol. 2016 Aug;57(8):985-91.

Calzada Sierra DJ, Gomez FL, Maragoto C. Neurorehabilitation in multiple sclerosis. Rev Neurol. 2001 Nov 16;33(10):1000.

Robinson Agramonte MA. Translational Approaches to Autism Spectrum Disorder. Heidelberg: Springer; 2015.

Inga Jacome MC, Morales Chacon LM, Vera CH, Maragoto RC, Whilby SM, Ramos HL, et al. Peripheral Inflammatory Markers Contributing to Comorbidities in Autism. Behav Sci (Basel). 2016 Dec 14;6(4).





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